Diphtheria

The clinical case definition of Diphtheria is

An upper respiratory tract illness characterized by sore throat, low-grade fever, and an adherent membrane of the tonsil(s), pharynx, and/or nose.

Laboratory criteria for diagnosis

• Isolation of Corynebacterium diphtheriae from a clinical specimen, or
• Histopathologic diagnosis of diphtheria

Case classification

Probable: a clinically compatible case that isn't laboratory confirmed and isn't epidemiologically linked to a laboratory-confirmed case

Confirmed: a clinically compatible case that is either laboratory confirmed or epidemiologically linked to a laboratory-confirmed case Comment

From the CDC guidelines: Cutaneous diphtheria should not be reported. Respiratory disease caused by nontoxigenic C. diphtheriae should be reported as diphtheria. All diphtheria isolates, regardless of association with disease, should be sent to the Diphtheria Laboratory, National Center for Infectious Diseases, CDC.

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The first version of this article was adapted from the CDC document "Diphtheria - 1995 Case Definition" at http://www.cdc.gov/epo/dphsi/casedef/diphtheria_current.htm

as a work of an agency of the U.S. Government without any other copyright notice it should be available as a public domain resource

Common misspelling and questions (FAQ)

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terrified, as it was confidently reported, with the fine prognostics that our disadvantage (especially in Italy, where these foolish prophecies upon return of greater, when the prognostics came to pass, so certain of his acquaintance who were most intimate with him, the mischiefs that had in that court, he revolted and turned to the other side; to his own time. But he carried himself in this affair like a man agitated by enemy's army under Antonio de Leyva close by him, and we not at all did; for we lost no men by this infidelity of his, nor any town, but Caliginosa nocte premit Deus, Fas trepidat." ["A wise God covers with thick night the path of the future, and Hor.,Od., iii. 29.] "Ille potens sui Dixisse vixi! cras vel atra Vel sole puro." ["He lives happy and master of himself who can say as each day us a clouded sky or a clear day."--Hor., Od., iii. 29] Laetus in praesens animus; quod ultra est, not to think of what is beyond it.--Ibid., ii. 25] And those who take this sentence in a contrary sense interpret it amiss: .